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Development of a fluorescence-based protease biosensor using nanoscale platforms
(University of Missouri--Columbia, 2010)
The development of a protease biosensor utilizing nanomaterials is presented in this dissertation. Peptide substrates and nanomaterial platforms were investigated to increase the sensitivity and response time for the detection of protease analytes...
Development of a fluorescence resonance energy transfer optical nanoscale biosensor based on a liquid-core waveguide platform
(University of Missouri--Columbia, 2007)
In order to produce a more versatile, adaptable, and effective method for detection of biological analytes, a self-contained and robust fluorescent optical biosensor architecture utilizing fluorescence resonance energy ...
Direct-from-sputum rapid phenotypic drug susceptibility test for mycobacteria
(University of Missouri--Columbia, 2018)
The spread of multi-drug resistant tuberculosis (MDR-TB) is a leading global public-health challenge. Because not all biological-mechanisms of resistance are known, culture-based (phenotypic) drug-susceptibility testing ...
Molecularly imprinted polymer labeled with quantum dots for detection of nitroaromatic explosives
(University of Missouri--Columbia, 2010)
A sensing device for explosive compounds is a fundamental step towards the capability to detect the presence of landmines, improvised explosive devices (IEDs), and other unexploded ordinance. To detect high explosive ...
A fiber-optic confocal scanner for scattering tissue
(University of Missouri--Columbia, 2009)
on the micrometer scale. While commercial confocal microscopes are readily available, they may not be suitable for examining tissues in vivo or able to accommodate large samples. The presented work offers a prototype device based on the principle of confocal...
Automated detection of amperometric spikes resulting from quantal exocytosis and estimation of spike and pre-spike foot signal parameters
(University of Missouri--Columbia, 2018)
Electrochemical microelectrodes can detect single-vesicle release events as "spikes" of amperometric current. We developed a template based "matched-filter" approach that performs least squares fit of a library of templates ...
Electrospinning lecithin-polycaprolactone scaffolds with gold nanoparticles for osteoarthritis prevention
(University of Missouri--Columbia, 2018)
The human body has articular cartilage covering the ends of the bones to act as a shock absorber and aid in movement. In a disease state, this articular cartilage breaks down causing pain, swelling, and stiffness. With ...
Fibrous soy protein meat analog from low moisture twin-screw extrusion
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Mixtures of soy protein isolate (SPI), defatted soy flour, and wheat flour were extruded at 34% (w.b.) moisture using a twin-screw extruder. A 3x3x3 ...
Design and characterization of a hand-held, waveguide-mediated, optoacoustic imaging probe for analyzing burn wounds
(University of Missouri--Columbia, 2018)
Clinicians correctly diagnose only [about]66% of burn wounds, which may be in part due to the qualitative methods commonly employed for burn assessment. This often results in over diagnoses, which may lead to unnecessary ...